Vitamin D–binding protein and pancreatic cancer: a nested case-control study
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چکیده
منابع مشابه
Vitamin D-binding protein and pancreatic cancer: a nested case-control study.
BACKGROUND Vitamin D-binding protein (DBP) is the primary carrier of 25-hydroxyvitamin D [25(OH)D] in the circulation. One prospective study in male smokers found a protective association between DBP and pancreatic cancer, particularly among men with higher 25(OH)D concentrations. OBJECTIVE The objective was to examine the association between DBP and pancreatic cancer risk in an American popu...
متن کاملA prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers.
Sun exposure is associated with lower death rates for pancreatic cancer in some ecological studies. Skin exposure to UVB light induces cutaneous production of precursors to 25-hydroxyvitamin D [25(OH)D]. Pancreatic islet and duct cells express 25(OH)D(3)-1alpha-hydroxylase that generates the biologically active 1,25(OH)(2) vitamin D form. Thus, 25(OH)D concentrations could affect pancreatic fun...
متن کاملStatus and Pancreatic Cancer Risk in Male Smokers A Prospective Nested Case-Control Study of Vitamin D
Sun exposure is associated with lower death rates for pancreatic cancer in some ecological studies. Skin exposure to UVB light induces cutaneous production of precursors to 25-hydroxyvitamin D [25(OH)D]. Pancreatic islet and duct cells express 25(OH)D3-1A-hydroxylase that generates the biologically active 1,25(OH)2 vitamin D form. Thus, 25(OH)D concentrations could affect pancreatic function an...
متن کاملVitamin D Receptor Gene Polymorphism and the Risk of Colorectal Cancer: A Nested Case-Control Study
Epidemiological and experimental evidence suggest that vitamin D is protective against the risk of colorectal cancer. Polymorphisms in the gene encoding vitamin D receptor (VDR), which mediates most of the known cellular effects of vitamin D, have been suggested to alter this association. Here, using a tag SNP approach, we comprehensively evaluated the role of common genetic variants in VDR and...
متن کاملHuman oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study.
OBJECTIVE A history of periodontal disease and the presence of circulating antibodies to selected oral pathogens have been associated with increased risk of pancreatic cancer; however, direct relationships of oral microbes with pancreatic cancer have not been evaluated in prospective studies. We examine the relationship of oral microbiota with subsequent risk of pancreatic cancer in a large nes...
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ژورنال
عنوان ژورنال: The American Journal of Clinical Nutrition
سال: 2015
ISSN: 0002-9165,1938-3207
DOI: 10.3945/ajcn.114.096016